Having a lot of Twitter followers is not that hard. After all, there are endless apps that will let you accumulate a number as large enough as you could ever wish for.
Now, whether or not they are going to be loyal (IE, stick around for longer than a tweet) is an entirely different matter. But there are tools such as InstaFollow available, IE tools that will enable you not to follow or be followed massively by others, but rather to bring relevance into the equation. Through it, you can start following people who have something (or even a lot) to do with you. That is infinitely more fulfilling than following any old Jack and hitting “unfollow” after just a couple of tweets.
The way it all works is very simple indeed, as all you have to do is login using your Twitter credentials and then enter you interests in order to be matched with people who are compatible. It is as easy as that, and the one and only niggle within range is that OAuth is not supported. Maybe the team behind it would like to work on that.
InstaFollow.com In Their Own Words
“Find and follow new Twitter users based on your interests by instafollow.com”
Why InstaFollow.com It Might Be A Killer
It is a good way to get acquainted with people that actually have something to do with you, not mere utter strangers that will turn their back after just three or four tweets.
Some Questions About InstaFollow.com
Can you carry out searches that take into account more interests than one at the same time? 
